Description of Visfatin Adipokine and its Roles on Inflammation and Coronary Heart Disease

Coronary heart disease (CHD) is a generic designation for group of related syndromes resulting from myocardial ischemia – an imbalance between cardiac blood supply (perfusion) and oxygen demand. Visfatin (VF) recently discovered adipokine with different functions, mainly found in visceral adipose tissue mimics insulin lowering plasma glucose levels and, emerges as player the development progression atherosclerotic lesions by directly promoting smooth muscle cell proliferation, Aberrant angiogenesis now considered feature atherogenic process both coronary carotid diseases. This was previously known pre-B-cell colony-enhancing factor (PBEF) or Nicotinamide phosphoribosyltransferase (NAmPRTase Nampt) enzyme that humans encoded NAMPT gene demonstrated to be intracellular protein key role nicotinamide adenine dinucleotide (NAD)